Browsing by Author "Pinarbasi, Hatice"
Now showing items 1-12 of 12
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The association between polymorphisms in glutathione S-transferase (GSTM1 and GSTT1) and lung cancer outcome
Gonlugur, Ugur; Pinarbasi, Hatice; Gonlugur, Tanseli Efeoglu; Silig, Yavuz (TAYLOR & FRANCIS INC, 2006)Background: Polymorphisms in the glutathione S-transferase (GST) family may be associated with increased risk of lung cancer, somatic changes in lung tumour tissue, and survival. We evaluated survival according to GST ... -
Association between the soluble epoxide hydrolase gene and preeclampsia
Sari, Ismail; Pinarbasi, Hatice; Pinarbasi, Ergun; Yildiz, Caglar (TAYLOR & FRANCIS INC, 2017)Objective: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women.Methods: ... -
AXIN2 polymorphism and its association with astrocytoma in a Turkish population
Gunes, Emine Gulsen; Pinarbasi, Ergun; Pinarbasi, Hatice (SPANDIDOS PUBL LTD, 2010)The product of AXIN2, a component of Writ signalling, plays a role in tumorigenesis and is dysregulated in cancer cells. In order to determine whether the AXIN2 polymorphism is a risk factor for astrocytoma, we analysed ... -
AXIN2 polymorphism and its association with prostate cancer in a Turkish population
Pinarbasi, Ergun; Gunes, Emine Gulsen; Pinarbasi, Hatice; Donmez, Gonca; Silig, Yavuz (HUMANA PRESS INC, 2011)Polymorphism of AXIN2, a component of Wnt signaling, has been shown to play a role in tumorigenesis and dysregulated in cancer cells. In order to find out if AXIN2 polymorphism is a risk factor for prostate cancer, we ... -
CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
Lee, Kyoung-Mu; Kang, Daehee; Clapper, Margie L.; Ingelman-Sundberg, Magnus; Ono-Kihara, Masko; Kiyohara, Chikako; Min, Shen; Lan, Qing; Le Marchand, Loic; Lin, Pinpin; Lung, Maria Li; Pinarbasi, Hatice; Pisani, Paola; Srivatanakul, Petcharin; Seow, Adeline; Sugimura, Haruhiko; Tokudome, Shinkan; Yokota, Jun; Taioli, Emanuela (AMER ASSOC CANCER RESEARCH, 2008)evaluate the roles of CYP1A1 polymorphisms [Ile (462)Val and (TC)-C-6235 (MspI)] and deletion of GSTM1 and and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies ... -
An investigation of the relationship between SULT1A1 Arg(213)His polymorphism and lung cancer susceptibility in a Turkish population
Arslan, Serdal; Silig, Yavuz; Pinarbasi, Hatice (WILEY-BLACKWELL, 2009)Human sulfotransferase 1A1 (SULT1A1), the most expressed isoform of the phenol SULT1 subfamily, is an important member of sulfotransferase superfamily. A transition, G to A at position 638, in SULT1A1 gene, results in ... -
Manganese-superoxide dismutase (MnSOD) polymorphisms
Silig, Yavuz; Tas, Ayca; Pinarbasi, Hatice (WALTER DE GRUYTER GMBH, 2015)Objective: Manganese superoxide dismutase (MnSOD, SOD2), the only known superoxide scavenger in mitochondria, may be particularly important for antioxidant defense because mitochondria are the major sites for cellular ... -
Microsomal epoxide hydrolase polymorphisms
Pinarbasi, Hatice; Silig, Yavuz; Pinarbasi, Ergun (SPANDIDOS PUBL LTD, 2010)Microsomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic sites have been described in exons 3 and 4 of the microsomal epoxide hydrolase gene that change ... -
Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population
Arslan, Serdal; Pinarbasi, Hatice; Silig, Yavuz (SPANDIDOS PUBL LTD, 2011)Myeloperoxidase (M PO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines. The MPO gene contains a common single nucleotide polymorphism, ... -
Role of SOD2 Ala16Val polymorphism in primary brain tumors
Tas, Ayca; Silig, Yavuz; Pinarbasi, Hatice; Gurelik, Mustafa (SPANDIDOS PUBL LTD, 2019)The present study aimed to investigate the possible association between the genetic polymorphism of the enzyme superoxide dismutase 2 (SOD2, also known as manganese-dependent SOD), Ala16Val (rs4880), and primary brain tumor ... -
Strong association between lung cancer and the AXIN2 polymorphism
Gunes, Emine Gulsen; Pinarbasi, Ergun; Pinarbasi, Hatice; Silig, Yavuz (SPANDIDOS PUBL LTD, 2009)Accumulated evidence suggests that alterations due to mutations or genetic polymorphisms in the AXIN2 tumor suppressor gene, a component of the Wnt signaling pathway, contributes to carcinogenesis. The effect of the AXIN2 ... -
Sulfotransferase 1A1 Arg(213)His polymorphism and prostate cancer risk
Arslan, Serdal; Silig, Yavuz; Pinarbasi, Hatice (SPANDIDOS PUBL LTD, 2011)Sulfotransferase 1A1 (SULT1A1) is a member of the sulfotransferase family that plays an important role in the biotransformation of numerous carcinogenic and mutagenic compounds through sulfation. A transition, G to A at ...